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Unlike other hypnotics, orexin antagonists may cause some dysregulation of REM sleep as is encountered in narcolepsy. LearnEnglish Teens can help improve your English with reading, writing and listening practice, tips for exams, grammar and vocabulary exercises, games and videos. In humans, the diurnal variation in cerebrospinal fluid CSF orexin levels seems much smaller 46 , 47 , but this is probably because CSF is generally collected from the lumbar region, far from the major sites of release. Orexin peptide knockout mice also seem to have severe sleepiness, with an inability to maintain long bouts of wakefulness during their active period 50 , Yoga fan is ready to work with trainer's huge dong
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